ozonated oil

What is Ozonated Oil?

Ozonated Oil products (based on olive oil, sunflower oil or others) provide a variety of scientifically and medically proven health benefits (see references below). They are used in cosmetics, skin care, beauty care, medical / pharmaceutical, food and animal products.

Commonly used to naturally treat many common conditions, some of the main benefits and typical uses of Ozonated Oils include:

  • Regenerates and repairs the skin helping the healing process
  • Protects, moisturises and nourishes the skin
  • Cleans and sterilizes the epidermis
  • Improves blood circulation
  • Controls and prevents the spread of germs in some skin conditions (seborrhea, acne, ringwork, skin lesions).
  • Reduces swelling and inflammation
  • Improves cellular function and cellular memory
  • Helps repair damaged skin conditions such as redness, bedsores, sunburn, wrinkles,
  • Helps avoid the use of more aggressive medical treatments such as corticosteroid creams
  • Aids in the healing processes reduces scarring, soothes sore muscles
  • Reduces incidence of degenerative skin conditions
  • Remedy for sunburn, wrinkles, insect bites and stings
  • Infections of the sebaceous glands (sweat)
  • Other uses: haemorrhoids, cuts and burns, skin yeast, tinea versicolor, dermatitis

How are Ozonated Oils made?

Ozonated Oils are made from lipid oxidation, a product of the reaction of ozone with fatty acids and other substrates contained in vegetable oils. These compounds have germicidal, immunostimulant and tissue repair activity, which is why they are being applied today as a new strategy for the treatment of infections and different pathologies.1-4

Ozone has a very short life time and at room temperature it returns to its oxygen state in less than a minute; this limits its use. This is where vegetable oils come in. When mixed with ozone it modifies the chemical structure of vegetable oils and allows the ozone to be stored in a stable and active manner for several years. 1-4

Through these ozone / vegetable oil chemical reactions, pharmacological active ingredients are produced with high added value without changing the rest of the molecule. The compounds that are formed when ozonating the oil are: ozonides, peroxides and aldehydes; all three are substances with proven germicidal properties.1-6 The physical properties of the oil allow it to penetrate places where other aqueous antibiotics do not reach, such as alveolitis in the root canals of the teeth.1-6


Since the late 1800s, the use of sunflower, coconut and cod liver oils has been described in patients with different conditions, mainly tuberculosis. The oils were prepared by enriching them with oxygen and exposing them to UV radiation from the sun.7

Currently, the applications for ozonated vegetable oil has spread rapidly, as well as its by-products which turn out to be novel compounds, appropriate for the topical treatment of various diseases such as: skin infections, nail fungus, diabetic foot, parasitosis, papillomatosis, traumatic lesions, infected wounds, ulcers, eschar, herpetic lesions, fungal infections, insect bites, dermatitis, skin in an inflammatory phase due to atopic dermatitis, interdigital itching, psoriasis, vaginal infections and disorders, burns, and infectious processes stomatological, among others.7-25

Often, many of these pathologies are beyond the control of conventional antibiotics; for example, in the regeneration of the skin due to wounds, burns, skin and mouth ulcers. In this scenario, factors such as microbial resistance and social elements play a role, which can be easily addressed with the appropriate dosage treatment. In this regard, Ozonated Oil turns out to be efficient, low-cost, and widely available alternatives.

These products have even been used in the treatment of radio-dermatitis secondary to cancer radiotherapy as complementary therapy. In addition to their economic advantage, ozonides satisfactorily have passed pre-clinical tests for dermal and ophthalmic irritability, acute and sub-chronic toxicity studies, mutagenicity and teratogenicity tests, which guarantee their safety.7,22 Additionally, they have other properties that give them a high degree of importance in terms of: stability, long shelf life, tolerance, low surface tension, it is soluble in fat and does not dry out, thus preventing the formation of crusts and cracks.7,22

Ozonated oil therapy
“The art of medicine consists in amusing the patient while nature cures the disease.” –  Voltaire

Why search for concentrated ozone in an oil?

The answer is simple: many of the drugs that previously turned out to be efficient, have stopped giving the expected results. In some cases the doses have to be increased and in others, the side effects are very harmful.

It is important to mention that worldwide, the use of ozone for therapeutic purposes is being imposed on a sustained basis, without neglecting the support of specialist doctors; This is called Ozone-Oxygen Therapy. 3, 7, 22, 25  This type of therapy is available today as are creams and ointments for topical use for the treatment of skin caused by fungi and bacteria, highly resistant to conventional treatments. Also soaps for therapeutic use are available produced from the saponification of synthesized ozonides. Furthermmore, there are numerous drugs and cosmetics on the market that use ozonized oils as their active ingredient.

Are all vegetable oils useful in the preparation of Ozonated Oil?

Before answering this question, we could ask the following question: where do vegetable oils come from? They are a reserve food product and are necessary for plant cells to start the germination process of seeds inside some fruits.

Vegetable oils are mainly made up of triglycerides and, depending on their origin, their composition of saturated and unsaturated fatty acids can vary (Fig.1).26 All vegetable oil can in principle be ozonized. However, the reaction of ozone with vegetable oils occurs through the double bonds of unsaturated fatty acids (Figure 2), with a greater number of unsaturations, there will also be more sites available in the molecule that can react with ozone and the activity of the final product may be increased.

Vegetable OilSaturated (%)Monounsaturated (%)Polyunsaturated (%)
Fig.1 Composition of some vegetable oils.
Classification of fatty acids
Fig. 2 Classification of fatty acids commonly found in vegetable oils.

One of the oils that has given the best results, in terms of its antimicrobial activity, is sunflower seed oil.3,19 This is attributed, particularly, to the amount of polyunsaturated fats it contains.

Oils hold varying amounts of ozone depending on the oil, which can be measured. The Potential Ozonide Index (POI) is determined by measuring the Omega 3, 6, and 9 fatty acids in the oil. Oils with higher 9s hold more ozone. Each oil has a different amount of 3, 6, and 9 fatty acids and each fatty acid is weighed differently. Every one has its own unique benefits as well as different level of ozone saturation levels it can obtain. Coconut holds lower amounts of than other oils, making it ideal for those who want to use ozone but prefer lower levels of intensity, for example.

Below is a chart indicating the POI for some common vegetable oils. The Formula used is:

Omega 3 (x3) + Omega 6 (x2) + Omega 9 (x1) = POI

Vegetable OilOmega 3Omega 6Omega 9Strength (POI)
Fig. 3 POI (Potential Ozonide Index) for some common vegetable oils.

What are the benefits of Ozonated Oil?

Some of the benefits of Ozonated Oil include:

  • It is 100% organic.
  • Does not require additives such as stabilizers, preservatives and colorants.
  • In topical application it is activated by the body temperature releasing oxygen to the skin.
  • The release process can take up to twelve hours or more (extended release).
  • It is safe and non-toxic.
  • It is one of the most advanced and proven products on the market. Ozonated Oil has been known since the 1800s. Many current patents have existed for 40 years.
  • It is so stable that it can last indefinitely if kept refrigerated.
  • Has similar or superior effects to traditional antibiotics.
  • A broad antimicrobial spectrum
  • A low rate of adverse events
  • Facilitates cost reduction compared to conventional treatments

What type of products are marketed using Ozonated Oil as the active ingredient?

Ozonated Oil products that are being marketed worldwide include: extracts, creams, ointments, gels, ovules, soft capsules and suppositories among others.

Ozonated Oils are also used extensively in the cosmetic market as the active ingredient for antibacterial soaps, deodorants (they do not require aluminum hydroxide), toothpastes, anti-aging creams, regenerative creams and special creams (for normal, dry, sensitive and oily skin types).

Currently, there are a wide variety of products on the market for specific ailments and conditions that use Ozonated Oil as the main active ingredient. For example, to fight acne, since it acts directly against the propionibacterium acnes bacteria.

The application of Ozonated Oil has spread to many countries. Ozonated Oil is considered by many doctors around the world as an alternative of great value because not only does it replace a large number of medicines but it is also relatively low cost, compared to conventional therapies, making it quite attractive.

ozonated oil


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