Ozonated oil offers a scientific research backed alternative to traditional wound care, particularly for chronic or infection-prone wounds and burns. It is very effective with many types of wounds and skin conditions due to its potent antimicrobial, anti-inflammatory and regenerative properties. It has been studied extensively for its wide reaching range of applications and benefits.
Ozonated oils have demonstrated significant antimicrobial effects, particularly against pathogens like Staphylococcus aureus, inc. methicillin-resistant strains (MRSA), which typically infect chronic wounds and diabetic ulcers. Clinical studies involving animal models, such as diabetic rats with MRSA-infected wounds, showed that ozonated oil effectively reduced bacterial loads on MRSA infected wounds and supported wound healing by enhancing epidermal regeneration and also by significantly reducing the infection´s severity.
Various types of wounds and ulcers. Source: Sabine et al, “Wound repair and regeneration…”
Research has shown ozonated oil promotes wound healing through a number of different actions and mechanisms. It enhances oxygenation, boosts local blood flow, and promotes the formation of growth factors necessary for tissue repair. Its ability to release reactive oxygen species (ROS) helps neutralize bacteria, viruses and fungi as well as reducing oxidative stress and inflammation making it particularly effective in treating wounds with high infection risk. Additionally, ozonated oil supports cellular signaling, which activates immune responses which are quite essential for wound healing. The antioxidant effect supports cellular repair and tissue regeneration, accelerating wound closure. Also, ozonated oil use has been shown to initiate key molecular responses essential for healing, such as cytokine release and leukocyte recruitment.
Furhtermore, studies have shown that ozonated oils are as effective as some conventional antifungal creams for conditions like vulvovaginal candidiasis. This makes ozonated oil a valuable option for wounds with secondary infections.
In comparison to non-ozonated oil treatments, ozonated oil formulations result in better healing abilities. Clinical research has shown that wounds treated with ozonated oil not only healed faster but also had a reduced risk of infection relapse. Hence ozonated oil is extremely helpful for wound care, especially where traditional treatments may fail or where antibiotic resistance is a concern.
Many clinical studies indicate ozonated oil can be very beneficial for chronic wounds, pressure ulcers, burns, surgical wounds, diabetes foot ulcers and skin ulcers in conditions such as diabetes.
REFERENCES
Liu J, Zhang P, Tian J, Li L, Li J, Tian J, Yang K. Ozone therapy for treating foot ulcers in people with diabetes. Cochrane Database of Systematic Reviews 2015, Issue 10. Art. No.: CD008474. DOI: 10.1002/14651858.CD008474.pub2.
Anzolin AP, da Silveira-Kaross NL, Bertol CD. Ozonated oil in wound healing: what has already been proven? Med Gas Res. 2020 Jan-Mar;10(1):54-59. doi: 10.4103/2045-9912.279985. PMID: 32189671; PMCID: PMC7871935.
Oğuzkan, S.B.; Kaya, S.T.; Cesur, A.; Karagül, B.; Uğraş, S.; Uğraş, H.I. Determination of Effect on Cutaneous Wound Healing of Ozonated Hazelnut Oil. Proceedings 2018, 2, 1537.
Qing Wen, Dongying Liu, Xian Wang, Yanli Zhang, Song Fang, Xianliang Qiu, Qiu Chen, A systematic review of ozone therapy for treating chronically refractory wounds and ulcers, First published: 06 October 2021
Silva, V.; Peirone, C.; Capita, R.; Alonso-Calleja, C.; Marques-Magallanes, J.A.; Pires, I.; Maltez, L.; Pereira, J.E.; Igrejas, G.; Poeta, P. Topical Application of Ozonated Oils for the Treatment of MRSA Skin Infection in an Animal Model of Infected Ulcer. Biology 2021, 10, 372.
Ugazio, E.; Tullio, V.; Binello, A.; Tagliapietra, S.; Dosio, F. Ozonated Oils as Antimicrobial Systems in Topical Applications. Their Characterization, Current Applications, and Advances in Improved Delivery Techniques. Molecules 2020, 25, 334.
Astasio-Picado Á, Babiano AÁ, López-Sánchez M, Lozano RR, Cobos-Moreno P, Gómez-Martín B. Use of Ozone Therapy in Diabetic Foot Ulcers. J Pers Med. 2023 Sep 27;13(10):1439. doi: 10.3390/jpm13101439. PMID: 37888050; PMCID: PMC10608575.